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PUBLICATIONS

Involvement of the Na+, K+-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors.

Horesh N, Pelov I, Pogodin I, Zannadeh H, Rosen H, Mikhrina AL, Dvela-Levitt M, Sampath VP, Lichtstein D.

International Journal of Molecular Sciences 2024

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FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Coraor Fried J, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A.

Cell Metabolism 2023

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Feed the Flames. Stories in Molecular Medicine.

Dvela-Levitt M.

Trends in Molecular Medicine 2021

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A rare kidney disease to cure them all? Towards mechanism-based therapies for proteinopathies.

Dvela-Levitt M, Shaw LJ, and Greka A. 

Trends in Molecular Medicine 2021

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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for

Alimova M, Sidhom E, Satyam A, Dvela-Levitt M, Melanson M, Chamberlain1 BT, Alper SL, Santos J, Gutierrez J, Subramanian A, Grinkevich E, Bricio ER, KimC, Clark A, Watts A, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam F, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka.

Cell Reports Medicine 2020

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Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy.

Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter T, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JCH, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A.

Cell. 2019

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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A.

Science. 2017

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Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.

Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygün O, Udeshi ND, Carr SA, Greka A.

J Biol Chem. 2017

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Reduction in maternal circulating ouabain impairs offspring growth and kidney development.

Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Ornoy A, Hochner-Celnikier D, Granat M and Lichtstein D. 

J. Am. Soc. Nephrol. 2015

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Ouabain improves functional recovery following traumatic brain injury.

Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Shohami E and Lichtstein D.

J Neurotrauma. 2014

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Cardenolides and bufadienolides as hormones: What is missing?

Lichtstein D, Rosen H and Dvela M.

Am. J. Physiol. Renal Physiol. 2012

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Endogenous ouabain regulates cell viability

Dvela M, Rosen H, Cohen-Ben Ami H and Lichtstein D.

Am J Physiol Cell Physiol. 2012

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Endogenous Ouabain-Like Compounds in Locus Coeruleus Modulate Rapid Eye Movement Sleep in Rats.

Jaiswal M, Dvela M, Lichtstein D and Mallick B.

J. Sleep Res. 2010

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Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Cohen Ben-Ami H, Rosen H and Lichtstein D.

Br. J. Pharmacol. 2010

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Physiological roles of endogenous ouabain in normal rat. 

Nesher M, Dvela M, Igbokwe VU, Rosen H, and Lichtstein D.

Am. J. Physiol. Heart Circ Physiol. 2009

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Diverse biological responses to different cardiotonic steroids

Dvela M, Rosen H, Feldmann T, Nesher M and Lichtstein D.

Pathophysiology. 2007

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