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PUBLICATIONS

Feed the Flames. Stories in Molecular Medicine.

Dvela-Levitt M.

Trends in Molecular Medicine 2021

A rare kidney disease to cure them all? Towards mechanism-based therapies for proteinopathies.

Dvela-Levitt M, Shaw LJ, and Greka A. 

Trends in Molecular Medicine 2021

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for

Alimova M, Sidhom E, Satyam A, Dvela-Levitt M, Melanson M, Chamberlain1 BT, Alper SL, Santos J, Gutierrez J, Subramanian A, Grinkevich E, Bricio ER, KimC, Clark A, Watts A, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam F, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka.

Cell Reports Medicine 2020

Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy.

Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter T, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JCH, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A.

Cell. 2019

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A.

Science. 2017

Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.

Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygün O, Udeshi ND, Carr SA, Greka A.

J Biol Chem. 2017

Reduction in maternal circulating ouabain impairs offspring growth and kidney development.

Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Ornoy A, Hochner-Celnikier D, Granat M and Lichtstein D. 

J. Am. Soc. Nephrol. 2015

Ouabain improves functional recovery following traumatic brain injury.

Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Shohami E and Lichtstein D.

J Neurotrauma. 2014

Cardenolides and bufadienolides as hormones: What is missing?

Lichtstein D, Rosen H and Dvela M.

Am. J. Physiol. Renal Physiol. 2012

Endogenous ouabain regulates cell viability

Dvela M, Rosen H, Cohen-Ben Ami H and Lichtstein D.

Am J Physiol Cell Physiol. 2012

Endogenous Ouabain-Like Compounds in Locus Coeruleus Modulate Rapid Eye Movement Sleep in Rats.

Jaiswal M, Dvela M, Lichtstein D and Mallick B.

J. Sleep Res. 2010

Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Cohen Ben-Ami H, Rosen H and Lichtstein D.

Br. J. Pharmacol. 2010

Physiological roles of endogenous ouabain in normal rat. 

Nesher M, Dvela M, Igbokwe VU, Rosen H, and Lichtstein D.

Am. J. Physiol. Heart Circ Physiol. 2009

Diverse biological responses to different cardiotonic steroids

Dvela M, Rosen H, Feldmann T, Nesher M and Lichtstein D.

Pathophysiology. 2007

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